COUPLING OF DETONATION NANODIAMONDS (DNDs) WITH STILBENES: THE RESVERATROL CASE
The interest of science in compounds that have antioxidant, antitumoral and cardio protective properties and can be founded in food has risen in nowadays. The case of resveratrol, a stilbene founded in wine, originated from grape as response of the wine against the damages, is the biggest case of studies. Resveratrol took all this attention after the term of French Paradox that describe the low incidence of French population, in cardiovascular disease as they are known as a regular wine consumer. The evaluation of bioavailability and toxicity of resveratrol in organism has been conducted with both methods, in vitro and in vivo. A number of studies have given evidences about the pathways how resveratrol is metabolized, the mechanism of action and its pharmacokinetic properties. But even now that is clear how resveratrol metabolism works there are a lot of questions, but the question to take in consideration is: which is the best way to intake these compounds to produce a pharmacological effect? The key for a pharmacological effect is the bioavailability of non-metabolized resveratrol. Higher the quantity of non-metabolized resveratrol, higher is the pharmacological affect. Oral intakes from wine or supplements are the only ways of resveratrol delivery. Coupling the resveratrol with detonation nanodiamonds (DNDs) raises the bioavailability of resveratrol and its pharmacological effect.
DND; Resveratrol; Delivery
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